Epothilone A ( Epothilone A | Epothilone-A | EpoA )

产品货号. M18061 CAS No. 152044-53-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Epothilone A
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Epothilone A 是一种微管稳定剂，EC0.01 为 2 μM。
产品描述

Epothilone A is a taxol-like microtubule (MT) stabilizing agent.
体外实验

Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers. The apparent Ki value for Epothilone A is 1.4 μM by Hanes analysis and 0.6 μM by Dixon analysis. Epothilone A, is noted to be highly cytotoxic (IC50=0.05 μM) in vitro when applied to the human T-24 bladder carcinoma cell line. The binding affinity of Epothilone A to tubulin is of the same order of magnitude as the binding affinity of paclitaxel to tubulin based on competition assays. The IC50 for displacement of 100 nM of (3H) paclitaxel from the tubulin binding site is 3.6 μM for paclitaxel, 2.3 μM for Epothilone A, and 3.3 μM for patupilone.
体内实验

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同义词

Epothilone A | Epothilone-A | EpoA
通路

Others
靶点

Other Targets
受体

Tubulin
研究领域

Cancer
适应症

——

CAS Number

152044-53-6
分子量

493.66
分子式

C26H39NO6S
纯度

>98% (HPLC)
溶解度

DMSO : 125 mg/mL 253.21 mM;
SMILES

C[C@H]1CCC[C@H]2O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)/C(=C/c1csc(C)n1)/C
化学全称

(1R,5S,6S,7R,10S,14S,16S)-6,10-Dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione

1. Regueiro-Ren A , et al. Org Lett, 2001, 3(17), 2693-2696.

计算器

产品手册

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